EXPERIMENTAL KIDNEY TRANSPLANT
EXPERIMENTAL KIDNEY TRANSPLANT

Considerations

HOME
LEGISLATION AND ETHICAL ASPECTS
 
LEGISLATION
 
CONSIDERATIONS
BASIC CONCEPTS AND NOMENCLATURE
PROCEDURES
 
RENAL EXTRACTION
 
RENAL TRANSPLANT
 
ARTERY ANASTOMOSIS
 
VEIN ANASTOMOSIS
 
URETER ANASTOMOSIS
 
SUPERVISION PROTOCOL
PROBLEMS AND SOLUTIONS
VIDEO FILES
BRIEF CURRICULUM VITAE
PUBLICATIONS
ACKNOWLEDGEMENTS
CONTACT
WEBSITE VERSIONS
 
VERSIĶ EN CATALĀ
 
VERSIĶN EN ESPAŅOL

WHY IT IS IMPORTANT TO HAVE AVAILABLE TRANSPLANT IN VIVO MODELS?

i/Because it is not possible to do all the necessary experimental trials in human beings.

ii/ Because the experimental models allow comparative studies since it is possible.

    a/ to equal and fix conditions (environmental, race, sex, treatment, etc…)
    b/ to isolate variables
    c/ to assess mechanisms

It is important for the animals and for the trial success to guaranty the welfare of the experimental animals (legislation).

DIFERENCIES BETWEEN HUMAN AND RAT KIDNEY TRANSPLANT

i/ The methodology of rat renal transplant is very similar to that of humans but this last is different from rat in:

    a/ either the right or left kidney is grafted (the one available)
    b/ the kidney is gafted heterotopically into the iliac space
    c/ the recipient kidneys are not nephrectomized

In contrast, in rat:

    a/ the left kidney is always the one transplanted because it is anatomically easier: the left renal vessels are longer than the right ones, in rat;
    b/ it is orthotopically grafted into the abdominal vessels below the native kidney.
    c/ both native kidneys are nephrectomized to allow the study of the renal function of the graft.

ii/ Survival is the priority in humans, thus patients are dialyzed if necessary.
In rats, the priority is the functional study of the kidney graft, thus survival is only another variable to assess. In addition, despite it was sometimes necessary, it is not possible to dialyze a rat.

web design: www.h2ocomunicacio.com  web design
 
  Renal transplant and Nephrology website iherrero@renal-transplantation.com